【单选题】【消耗次数：1】
下列表现中提示骨巨细胞瘤出现恶变征象的是
①
骨性包壳和骨嵴残缺不全
②
骨膜反应较显著，可有Codman三角
③
软组织肿块较大，超出骨性包壳的轮廓
④
患者年龄较大，疼痛持续加重，肿瘤突然生长迅速并有恶病质
⑤
以上都对
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